Journal
ORGANIC LETTERS
Volume 20, Issue 10, Pages 3128-3131Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01228
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Funding
- Science and Engineering Research Board (SERB), the Department of Science and Technology, New Delhi [EMR/2016/006253, PDF/2017/000509]
- Council of Scientific and Industrial Research (CSIR), New Delhi [IICT/Pubs./2018/044]
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An unprecedented copper-catalyzed aminative aza-annulation of enynyl azide using commercially available N-fluorobenzenesulfonhnide (NFSI) as an amination reagent is described. The reaction proceeds via regioselective inter-/intramolecular diamination, incorporating one nitrogen from the NFSI and the other from the azide, to provide amino substituted nicotinate derivatives in a single step with moderate to high yield. This method represents an efficient way to access diverse aminonicotinates through direct C-N bond-coupling processes.
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