Journal
ORGANIC LETTERS
Volume 20, Issue 12, Pages 3447-3450Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01029
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Funding
- National Natural Science Foundation of China [21772029, 21472028]
- National Key Technologies RD Program [2014BAD23B01]
- Thousand Talent Plan
- Guizhou Province Returned Oversea Student Science and Technology Activity Program, Guizhou University
- Singapore National Research Foundation [NRF-NRFI2016-06]
- Ministry of Education of Singapore [MOE2013-T2-2-003, MOE2016-T2-1-032, RG108/16]
- A*STAR Individual Research Grant [A1783c0008]
- Nanyang Research Award Grant
- Nanyang Technological University
- Regione Lombardia-Cariplo Foundation Grant [B/2016]
- University of Pavia
- 10 Talent Plan (Shicengci) of Guizhou Province
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A kinetic resolution of 1,2-diols bearing both a secondary and a primary alcohol motif through an N-heterocyclic carbene-catalyzed oxidative acylation reaction has been developed. A site- and enantioselective esterification reaction is involved for this process. Both the monoacylated diols obtained and the remaining enantioenriched 1,2-diols are versatile building blocks for the preparation of functional molecules with proven biological activities.
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