4.8 Article

Nickel-Catalyzed System for the Cross-Coupling of Alkenyl Methyl Ethers with Grignard Reagents under Mild Conditions

Journal

ORGANIC LETTERS
Volume 20, Issue 7, Pages 1815-1818

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00313

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Funding

  1. Sanofi

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A nickel-catalyzed cross-coupling of alkenyl methyl ethers with Grignard reagents, under mild conditions, is described. These conditions allowed access to various stilbenes and heterocyclic stilbenic derivatives as well as to a potential anticancer agent DMU-212.

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