Journal
ORGANIC LETTERS
Volume 20, Issue 7, Pages 1928-1931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00476
Keywords
-
Categories
Ask authors/readers for more resources
A transglycosylation reaction of 2'-amino-locked nucleic acid (LNA) from thymine (T) to other nucleobases adenine (A), guanine (G), and 5-methylcytosine (C-m) has been developed. This reaction proceeds in high yield and with high beta-selectivity. The mild reaction conditions enable the coexistence of acid-labile protecting groups, including a 4,4'-dimethoxytrytyl (DMTr) group. 2'-Amino-LNAs bearing any nudeobase can now be easily synthesized.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available