Journal
ORGANIC LETTERS
Volume 20, Issue 7, Pages 1888-1892Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00433
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Funding
- Shenzhen Tech-Innovation Program from the Shenzhen Science, Technology and Innovation Commission
- Shenzhen Free Exploration Fund
- Shenzhen Research Grants [JSGG20160608140847864]
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An iridium/f-amphol catalytic system for the enantioselective hydrogenation of alpha-substituted beta-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity (up to 96:4 diastereometic ratio (dr)) and excellent enantioselectivity (up to >99% enantiomeric excess (ee)). A catalytic model is proposed to explain the stereoselectivity.
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