Journal
ORGANIC LETTERS
Volume 20, Issue 5, Pages 1400-1403Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00173
Keywords
-
Categories
Funding
- MEXT (Japan)
- Grants-in-Aid for Scientific Research [26220803, 17H06450] Funding Source: KAKEN
Ask authors/readers for more resources
A copper-catalyzed C(sp)-C(sp(3)) coupling reaction between terminal alkynes and alkylsilyl peroxides is reported. In the presence of a copper catalyst and 4-dimethylaminopyridine, the reaction smoothly affords a variety of internal alkynes by coupling alkylsilyl peroxides and terminal alkynes. Mechanistic studies suggest that the reaction proceeds via a radical mechanism, whereby the alkyl radicals are generated from the alkylsilyl peroxides. The present transformation represents a rare example of a radical-mediated C(sp)-C(sp(3)) coupling reaction of terminal alkynes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available