Journal
ORGANIC LETTERS
Volume 20, Issue 4, Pages 1179-1182Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00101
Keywords
-
Categories
Funding
- Research Grants Council of Hong Kong [CUHK 24301217]
- Chinese University of Hong Kong (the Faculty Strategic Fund for Research from the Faculty of Science)
- Chinese University of Hong Kong (Direct Grant for Research) [4053199]
Ask authors/readers for more resources
An unprecedented three-component copper-mediated vicinal trifluoromethylation-allylation of arynes is described. A wide range of structurally diverse trifluoromethylated allylarenes can be quickly assembled in one step. The application of the method has been demonstrated in the expedient synthesis of the CF3-containing analogue of the antispasmodic drug papaverine. The new reactivity of the [CuCF3] reagent, which is generated from the inexpensive industrial byproduct fluoroform, is revealed with unique advantages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
