Journal
ORGANIC LETTERS
Volume 20, Issue 9, Pages 2737-2740Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00945
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Funding
- KAKENHI from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [15K05500]
- Grants-in-Aid for Scientific Research [15K05500] Funding Source: KAKEN
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A silica-supported 3-aryl H-8-BINOL-derived titanium catalyst exhibited high performance in the enantioselective arylation of aromatic aldehydes using Grignard and organolithium reagents not only under batch conditions but also under continuous-flow conditions. Even with a simple pipet reactor packed with the heterogeneous catalyst, the enantioselective production of chiral diarylmethanols could be achieved through a continuous introduction of aldehydes and mixed titanium reagents generated from the organometallic precursors. The pipet reactor could be used repeatedly in different reactions without appreciable deterioration of the activity.
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