Journal
ORGANIC LETTERS
Volume 20, Issue 7, Pages 1914-1918Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00468
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Funding
- SERB [EMR/2014/385]
- CSIR, India
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A nontrivial Ru-catalyzed one-pot sequential oxidative coupling of a (hetero)arene/vinylic/chromene system with alkyne and quinone is presented; the methyl phenyl sulfoximine (MPS) directing group is vital. This cyclization forms four (two C-C and two C-N) bonds in a single operation and produces unusual spiro-fused-isoquinolones with a broad scope. The release of phenyl methyl sulfoxide makes the MPS group transformable. A deuterium scrambling study sheds light on the reaction path.
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