Journal
ORGANIC LETTERS
Volume 20, Issue 8, Pages 2365-2368Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00699
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Funding
- DFG [SFB749]
- LMU Munich
- FCI Foundation
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A copper(I)-mediated cross-coupling of stereo defined secondary alkyllithiums with bromoalkynes provided stereodefined alkynes with high diastereoselectivity (dr up to 98:2). This cross-coupling was extended to various secondary alkyllithiums bearing a remote oxygen functionality, and the alkyne synthesis was also performed with optically enriched alkyl iodides (up to 99% ee) providing, after cross-coupling, alkynes bearing two stereocenters (dr = 93:7; up to 99% ee).
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