Journal
ORGANIC LETTERS
Volume 20, Issue 11, Pages 3202-3205Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01043
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Funding
- National Key R&D Program of China [2017YFA0700100]
- NSFC [21502191, 21672213]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Haixi Institute of CAS [CXZX-2017-P01]
- 100 Talents Program
- 1000 Youth Talents Program
- Innovative Research Teams Program II of Fujian Normal University of China [IRTL1703]
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This paper reports a new method for the generation of substituted 1,3-enynes, whose synthesis by other methods could be a challenge. The dehydrative decarboxylative cascade coupling reaction of propargyl alcohol with alkyl peroxides is enabled by an iron catalyst and alkylating reagents. Primary, secondary, and tertiary alkyl groups can be introduced into 1,3-enynes, affording various substituted 1,3-enynes in moderate to good yields. Mechanistic studies suggest the involvement of a radical-polar crossover pathway.
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