Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 27, Pages 4958-4962Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00948a
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Funding
- National Natural Science Foundation of China [81622043]
- Natural Science Foundation of Zhejiang Province [LQ18BO20004]
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A versatile and efficient method for the synthesis of 3-chalcogenyl-indoles from indoles and dichalcogenides employing t-BuOK as a promoter at room temperature has been achieved. The present protocol exhibited a broad functional group tolerance. Diverse 3-sulfenyl- and 3-selenyl-indoles were rapidly obtained in good to excellent yields with high regioselectivities. It is noteworthy that this transformation was applicable to N-protected and N-unprotected indoles, allowing N-deprotection and C3-chalcogenylation of indoles in one step.
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