Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 23, Pages 4288-4294Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00897c
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Universite de Montreal [03866]
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We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.
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