Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 12, Pages 2006-2027Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00138c
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Funding
- Purdue University
- National Institutes of Health [GM53386]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM053386, R37GM053386] Funding Source: NIH RePORTER
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The Curtius rearrangement is a versatile reaction in which a carboxylic acid can be converted to an isocyanate through an acyl azide intermediate under mild conditions. The resulting stable isocyanate can then be readily transformed into a variety of amines and amine derivatives including urethanes and ureas. There have been wide-ranging applications of the Curtius rearrangement in the synthesis of natural products and their derivatives. Also, this reaction has been extensively utilized in the synthesis and application of a variety of biomolecules. In this review, we present mechanistic studies, chemical methodologies and reagents for the synthesis of isocyanates from carboxylic acids, the conversion of isocyanates to amines and amine derivatives, and their applications in the synthesis of bioactive natural products and their congeners.
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