Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 6, Pages 895-898Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob03040a
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Funding
- National Natural Science Foundation of China [21502043]
- Natural Science Foundation of Shandong Province [ZR2017JL011]
- National Key Research and Development Program of China [2016YFA0501403]
- Qingdao University
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The double [3 + 2]-cycloadditions between nitrile oxides and allenoates have been achieved. In the presence of DABCO combined with Et3N, 2-substituted buta-2,3-dienoates reacted with oxime chlorides to afford spirobiisoxazolines in 55-90% yields via the double 1,3-dipolar cycloaddition. Notably, the construction of double isoxazoline moieties and two chiral centers including a spiro carbon center was achieved.
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