Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 17, Pages 3282-3288Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00305j
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Funding
- Scientific and technological innovation development plan of Jilin Science and Technology Bureau [201750237]
- State Key Laboratory of Medicinal Chemical Biology (NanKai University) [2017001]
- National Natural Science Foundation of China [81773692]
- National Undergraduate Training Programs for Innovation and Entrepreneurship [201713743012]
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The development of a method for the Pd(II)-catalyzed denitrogenative coupling of arylhydrazines to give functionalized biaryls in good yield, using aryl bromides or aryl iodides as convenient and inexpensive aryl sources, is reported. High functional group tolerance is demonstrated for electronically distinct arylhydrazines as well as aryl halides. The desired products were isolated in good to excellent yields for 58 examples. Control experiments and mechanism studies revealed that the transformation undergoes a base-promoted Pd-catalyzed process.
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