Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 13, Pages 2198-2209Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00030a
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Funding
- NSF [DGE-1144676, EPS-0554328, EPS-1003907]
- Ratchadaphiseksomphot endowment fund
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Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B-Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.
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