Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 10, Pages 1620-1626Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob03127k
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Funding
- Australian Government Research Training Program PhD Scholarship
- International Postgraduate Research Scholarship
- Australian Research Council (ARC) Future Fellowship
- ARC Discovery Project grant [DP170100228]
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Fungi are a rich source of bioactive small molecules. However, the large number of biosynthetic gene clusters (BGCs) encoding these molecules in their genomes suggests their biosynthetic potential is far greater than we previously appreciated. The mining of fungal genomes therefore holds great promise for the discovery of new chemical entities for pharmaceutical and agricultural applications. As more and more fungal genomes become available, the accompanying number of BGCs is quickly becoming unmanageable. Along with improving molecular genetic tools to accelerate the translation of BGCs to small molecules, we must devise strategies to prioritise BGCs most likely to encode the biosynthesis of novel small molecules and molecules with new or improved bioactivities or functions. In this perspective, we discuss existing and emerging strategies for prioritisation of BGCs to increase the odds of fruitful genome mining in fungi.
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