Journal
OPTO-ELECTRONICS REVIEW
Volume 26, Issue 1, Pages 50-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.opelre.2018.01.001
Keywords
PCF-SPR biosensor; DNACE; Sensitivity; Resolution
Funding
- National Natural Science Foundation of China [51474069]
- China Postdoctoral Science Foundation [2016M591510]
- Natural Science Foundation of Heilongjiang Province [E2016007]
- City University of Hong Kong Applied Research Grant (ARG) [9667122]
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A highly sensitive photonic crystal fiber based on the surface plasmon resonance (PCF-SPR) biosensor for the detection of the density alteration in non-physiological cells (DANCE) is described. Human acute leukemia cells are determined by the discontinuous sucrose gradient centrifugation (DSGC) in which the cells are separated into several bands. The separated cells with different intracellular densities and refractive indexes (RI) ranging from 1.3342 to 1.3344 are distinguished in situ by means of the differential transmission spectrum. The biosensor shows a maximum amplitude sensitivity of 2000 nm/RIU and resolution as high as 5 x 10(-5) RIU. According to the wavelength interrogation method, a maximum spectral sensitivity of 9000 nm/RIU in the sensing range between 1.33 and 1.53 is achieved, corresponding to a resolution as high as 1.11 x 10(-5) RIU for the biosensor. The proposed PCF-SPR biosensor has promising application in biological and biochemical detection. (c) 2018 Association of Polish Electrical Engineers (SEP). Published by Elsevier B.V. All rights reserved.
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