Journal
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
Volume 7, Issue 3, Pages 183-191Publisher
SPRINGER HEIDELBERG
DOI: 10.1134/S1990747813040041
Keywords
purines; myoneural synapse; ATP; adenosine; synaptic modulation
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The data on purine modulation of myoneural transmission are reviewed. A particular attention is paid to adenosine-5'-triphosphoric acid (ATP), the co-transmitter of the principal mediator (acetylcholine), and adenosine, the final ATP metabolite in the synaptic cleft. The effects of these endogenous modulators on pre-and postsynaptic current are discussed. The contributions of purines to the process of quantal and non-quantal acetylcholine release into the synaptic cleft and the effects of ATP and adenosine on cholinoceptor function have been assessed. It is concluded that the role of endogenous purines is mainly confined to enhancement of the efficiency of neuromuscular transmission and synaptic adjustment of a motor unit at different modes of function.
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