Journal
NATURE REVIEWS CANCER
Volume 13, Issue 7, Pages 482-495Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrc3539
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Funding
- Breast Cancer Campaign
- Cancer Research UK
- Biomedical Research Unit in Reproductive Health
- University Hospitals Coventry
- Warwickshire NHS Trust
- Warwick Medical School
- Imperial College Healthcare NHS Trust
- Cancer Research UK [12011] Funding Source: researchfish
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Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.
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