Journal
NATURE REVIEWS CANCER
Volume 13, Issue 6, Pages 425-431Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3519
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Funding
- National Health and Medical Research Council of Australia
- Cancer Council New South Wales
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Protein action in nature is generally controlled by the amount of protein produced and by chemical modification of the protein, and both are often perturbed in cancer. The amino acid side chains and the peptide and disulphide bonds that bind the polypeptide backbone can be post-translationally modified. Post-translational cleavage or the formation of disulphide bonds are now being identified in cancer-related proteins and it is timely to consider how these allosteric bonds could be targeted for new therapies.
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