Journal
OPTICAL MATERIALS
Volume 75, Issue -, Pages 243-251Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.optmat.2017.10.030
Keywords
Europium(III) complex; Visible-light-excitation; Luminescent probe; Copper ions; Hydrogen sulfide
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Funding
- Undergraduate Training Programs for Innovation and Entrepreneurship of Liaoning Province [201510165033]
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Development of visible-light-excited lanthanide (III) complex-based luminescent probes is highly appealing due to their superiority of less damage to the living biosystems over the conventional UV-light-excited ones. In this work, a visible-light-excited europium (III) complex-based luminescent probe, BPED-BHHCT-Eu3+-BPT, has been designed and synthesized by conjugating the Cu2+-binding N,N-bis(2-pyridylmethyl)ethanediamine (BPED) to a tetradentate beta-diketone ligand 4,4'bis(1,1,1,2,2,3,3-heptafluoro-4,6-hexanedione-6-yl)chlorosulfo-o-terphenyl (BHHCT) and coordinating with a coligand 2-(N,N-diethylanilin-4-y1)-4,6-bis(pyrazol-1-y1)-1,3,5-triazine) (BPT) for the time-gated luminescence detection of Cu2+ ions and hydrogen sulfide (H2S) in living cells. BPED-BHHCT-Eu3+-BPT exhibited a sharp excitation peak at 407 nm and a wide excitation window extending to beyond 460 nm. Upon its reaction with Cu2+ ions, the luminescence of BPED-BHHCT-Eu3+-BPT was efficiently quenched, which could be reversibly restored by the addition of H2S due to the strong affinity between Cu2+ ions and H2S. The on-off-on type luminescence behavior of BPED-BHHCT-Eu3+-BPT towards Cu2+ ions and H2S enabled the sensing of the two species with high sensitivity and selectivity. The performances of BPED-BHHCT-Eu3+-BPT for visualizing intracellular Cu2+ ions and H2S were investigated, and the results have demonstrated the practical applicability of the probe for molecular imaging of cells. (C) 2017 Published by Elsevier B.V.
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