Journal
NEURAL REGENERATION RESEARCH
Volume 8, Issue 15, Pages 1360-1367Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.3969/j.issn.1673-5374.2013.15.002
Keywords
neural regeneration; traditional Chinese medicine; emodin; oxygen-glucose deprivation; activin A; apoptosis; caspase-3; neuroprotection; grants-supported paper; neuroregeneration
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Funding
- National Natural Science Foundation of China [30971037]
- Postdoctoral Foundation of China [2012MS10489]
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Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism. After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subjected to oxygen-glucose deprivation and treated with emodin. Results showed that the viability of neuron-like cells cultured under an ischemia-hypoxia environment decreased, while the expression of activin A and caspase-3 in cells increased. Emodin raised the survival rate of oxygen-glucose deprived neuron-like cells, increased activin A expression, and decreased caspase-3 expression. Experimental findings indicate that emodin can inhibit neuronal apoptosis and alleviate the injury of nerve cells after oxygen-glucose deprivation through the activin A pathway.
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