Journal
ONCOLOGY RESEARCH
Volume 26, Issue 8, Pages 1183-1189Publisher
TECH SCIENCE PRESS
DOI: 10.3727/096504018X15151495109394
Keywords
Liver cancer (LC); Proliferation; MicroRNA-338-3p; Sphingosine kinase 2 (SphK2)
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Funding
- Key Project of Medical Science Research in Hebei Province [20150335]
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Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably enhanced the growth suppression triggered by miR-338-3p in LC cells. These findings indicate that miR-338-3p influences the development of LC by targeting SphK2, suggesting that miR-338-3p can be targeted as an innovative therapeutic strategy for LC.
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