Journal
ONCOLOGY RESEARCH
Volume 26, Issue 5, Pages 683-690Publisher
TECH SCIENCE PRESS
DOI: 10.3727/096504017X14982585511252
Keywords
Pancreatic cancer (PC); miR-144-3p; FosB proto-oncogene; AP-1 transcription factor subunit (FOSB); Cell proliferation; Cell migration; Cell invasion
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This study aimed to investigate the role of miR-144-3p in pancreatic cancer (PC) carcinogenesis and to explore the mechanism of its function in PC. miR-144-3p was downregulated in PC tissues and cells. miR-144-3p overexpression significantly inhibited PC cell proliferation, migration, and invasion. FosB proto-oncogene, AP-1 transcription factor subunit (FOSB) was a target gene of miR-144-3p. miR-144-3p could repress PC cell proliferation, migration, and invasion by inhibiting the expression of FOSB. In conclusion, miR-144-3p plays an important role in PC cell proliferation, migration, and invasion by targeting FOSB. miR-144-3p may provide a new target for the development of therapeutic agents against PC.
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