Journal
ONCOLOGY REPORTS
Volume 39, Issue 3, Pages 1197-1206Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2018.6207
Keywords
papillary thyroid cancer; long non-coding RNA; competitive endogenous RNA; microRNA; The Cancer Genome Atlas
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Funding
- Chinese National Natural Science Foundation Grant [81671541, 81273202, 31400773]
- Clinical Medicine Science and Technology Project of Jiangsu Province of China [BL2013024]
- Postgraduate Research and Practice Innovation Program of Jiangsu Province [KYCX17_1820]
- China Scholarship Council
- Program of Innovative Research Team of Jiangsu Province
- Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions
- Project of the Key Academic Program Development of Jiangsu University [1291270019]
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Increasing evidence has experimentally proved the competitive endogenous RNA (ceRNA) hypothesis that long non-coding RNA (lncRNA) can affect the expression of RNA targets by competitively combining microRNA (miRNA) via miRNA response elements. However, an extensive ceRNA network of thyroid carcinoma in a large cohort has not been evaluated. We analyzed the RNAseq and miRNAseq data of 348 cases of primary papillary thyroid cancer (PTC) patients with clinical information downloaded from The Cancer Genome Atlas (TCGA) project to search for potential biomarkers or therapeutic targets. A computational approach was applied to build an lncRNA-miRNA-mRNA regulatory network of PTC. In total, 780 lncRNAs were detected as collectively dysregulated lncRNAs in all 3 PTC variants compared with normal tissues (fold change >2 and false discovery rate <0.05). The interactions among 45 lncRNAs, 13 miRNAs and 86 mRNAs constituted a ceRNA network of PTC. Nine out of the 45 aberrantly expressed lncRNAs were related to the clinical features of PTC patients. However, the expression levels of 3 lncRNAs (LINC00284, RBMS3-AS1 and ZFX-AS1) were identified to be tightly correlated with the patients overall survival (log-rank, P<0.05). The present study identified a list of specific lncRNAs associated with PTC progression and prognosis. This complex ceRNA interaction network in PTC may provide guidance for better understanding the molecular mechanisms underlying PTC.
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