Journal
ONCOLOGY
Volume 94, Issue 5, Pages 324-328Publisher
KARGER
DOI: 10.1159/000486680
Keywords
Combinations in oncology; Dendrimers; Camptothecin; Cisplatin; Paclitaxel; Doxorubicin; MG132
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Funding
- FCT - Fundacao para a Ciencia e a Tecnologia [PEst-OE/QUI/UI0674/2013]
- ARDITI - Centro de Quimica da Madeira - CQM+ (Madeira 14-20) [M1420-01-0145-FEDER-000005]
- CNRS (France)
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The metallo-phosphorus dendrimer 1G3-Cu (generation 3 dendrimer bearing 48 conjugated copper(II) on its surface) has antiproliferative activity related to its capacity to activate Bax translocation. In the present study, we evaluate the activity of an association of 1G3-Cu with 5 cytotoxic agents used in chemotherapy having different modes of action. Data show no additive effect with camptothecin and cisplatin, additivity with paclitaxel and MG132, and synergy with doxorubicin. Results suggest that the multivalent Cu-conjugated dendrimer 1G3-Cu ( activator of Bax translocation) plays an important role in boosting the clinical impact of Bax accumulation stimulated by the proteasome inhibitor MG132, antimitotic taxanes, and the topo II inhibitor doxorubicin. (C) 2018 S. Karger AG, Basel
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