Journal
BREAST CANCER RESEARCH
Volume 15, Issue 1, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/bcr3350
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Funding
- McNair Medical Institute
- National Cancer Institute [R00CA151293]
- Breast Cancer Research Foundation
- program of Molecular and Cellular Biology at the Baylor College of Medicine
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A recent Cell publication demonstrates that the secreted antagonist of transforming growth factor-beta ligands, Coco, can re-activate previously dormant metastatic breast cancer cells specifically in the lung by inhibiting bone morphogenetic protein (BMP) signaling. The authors provided evidence for a connection between Coco/BMP signaling and molecular and cellular traits of cancer stem cells. Their findings represent a significant advance in our understanding of metastatic dormancy, an extremely important clinical issue that remains understudied. Equally as important, this study also opens interesting avenues for future research.
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