Journal
OCULAR SURFACE
Volume 16, Issue 1, Pages 31-44Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtos.2017.10.001
Keywords
Dry eye; Genetics; Inflammation; Nerve sensitization; Neuropathic pain; Treatment
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Funding
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research [EPID-006-15S, R01EY026174]
- NIH Center [P30EY014801]
- Research to Prevent Blindness
- NIH NIDCR [R01 DE022903]
- Department of Anesthesiology, Perioperative Medicine, and Pain Management, University of Miami Miller School of Medicine, Miami, Florida
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Dry eye is a common, multifactorial disease currently diagnosed by a combination of symptoms and signs. Its epidemiology and clinical presentation have many similarities with neuropathic pain outside the eye. This review highlights the similarities between dry eye and neuropathic pain, focusing on clinical features, somatosensory function, and underlying pathophysiology. Implications of these similarities on the diagnosis and treatment of dry eye are discussed. Published by Elsevier Inc.
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