Journal
NUCLEIC ACIDS RESEARCH
Volume 46, Issue 8, Pages 3921-3936Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gky138
Keywords
-
Categories
Funding
- MEXT [16K07195, 24780070, 15K18670]
- MEXT Cooperative Research Program of Network Joint Research Center for Materials and Devices
- MEXT
- Grants-in-Aid for Scientific Research [16K07195] Funding Source: KAKEN
Ask authors/readers for more resources
The identification of regulatory targets of all TFs is critical for understanding the entire network of the genome regulation. The lac regulon of Escherichia coli K-12 W3110 is composed of the lacZYA operon and its repressor lacl gene, and has long been recognized as the seminal model of transcription regulation in bacteria with only one highly preferred target. After the Genomic SELEX screening in vitro of more than 200 transcription factors (TFs) from E. coli K-12, however, we found that most TFs regulate multiple target genes. With respect to the number of regulatory targets, a total of these 200 E. coli TFs form a hierarchy ranging from a single target to as many as 1000 targets. Here we focus a total of 13 single-target TFs, 9 known TFs (Betl, KdpE, Lacl, MarR, NanR, RpiR, TorR, UlaR and UxuR) and 4 uncharacterized TFs (Yagl, YbaO, YbiH and YeaM), altogether forming only a minor group of TFs in E. coli. These single-target TFs were classified into three groups based on their functional regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available