Journal
NATURE REVIEWS CANCER
Volume 13, Issue 7, Pages 511-518Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3536
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Funding
- US National Aeronautics and Space Administration (NASA) Specialized Center for Research in Radiation Health Effects [NNX09AM52G]
- Hartwell Foundation
- Children's Cancer and Blood Foundation
- Champalimaud Foundation
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The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a 'precancer niche' is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumour promotion and progression, respectively. As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy.
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