Journal
CANCER MICROENVIRONMENT
Volume 6, Issue 2, Pages 179-191Publisher
SPRINGER
DOI: 10.1007/s12307-012-0123-x
Keywords
Tumor-associated macrophages; Monocytes; Myeloid cells; Immunotherapy
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Funding
- Helmholtz Association of German Research Centers (HGF) [HZ-NG-505]
- HGF-PhD-fellowship
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Monocytes and tumor-associated macrophages are part of the myeloid family, a group of hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell-derived macrophages. After their recruitment into the tumor tissue, they can differentiate into tumor-associated macrophages, a very heterogeneous cell population in terms of phenotype and pro-tumor function, supporting tumor initiation, local progression and distant metastasis. Therefore, targeting monocytes and macrophages is a promising immunotherapeutic approach. This review will focus on the development of monocytes as macrophage precursors, the functions of tumor-associated macrophages and the possibility of interfering with tumor development and progression by targeting these myeloid cells.
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