Journal
NATURE REVIEWS CANCER
Volume 13, Issue 8, Pages 585-595Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3556
Keywords
-
Categories
Funding
- US Public Health Service [P01CA050661, R01CA63113]
Ask authors/readers for more resources
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available