4.5 Article

Changing Concepts and Findings on Autism

Journal

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 43, Issue 8, Pages 1749-1757

Publisher

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-012-1713-7

Keywords

Phenotypic overlap among disorders; Genetic overlap; Fractionable autism triad; Broader autism phenotype; Rett syndrome; Epilepsy

Funding

  1. Medical Research Council [G9817803B] Funding Source: researchfish

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New research findings provide major challenges regarding our understanding of the concept of autism. These are critically discussed in relation to research relevant to classification, genetics, environmental risk factors, gene-environment interplay, animal models, biomarkers, clinical features, neuropathology, pharmacotherapy, behavioral treatments, and functioning in adult life. It is concluded that, although there have been major research advances; there is a need for a reconceptualization and an avoidance of claims that go beyond the evidence.

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