Journal
NATURE REVIEWS IMMUNOLOGY
Volume 13, Issue 8, Pages 607-614Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri3476
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Funding
- US National Institutes of Health (NIH) [R01AI031678, R01AI066188]
- Intramural Research Program from the NIH National Institute of Allergy and Infectious Diseases
- MRC [MR/J001929/1, G0600818] Funding Source: UKRI
- Medical Research Council [G0600818, MR/J001929/1] Funding Source: researchfish
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Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.
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