Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 78, Issue -, Pages 170-175Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2018.03.012
Keywords
NO2-FA; NRF2; KEAP1; HSF1; Redox signaling
Categories
Funding
- Academy of Finland [275147]
- Jane and Aatos Erkko Foundation
- Sigrid Juselius Foundation
- Finnish Cancer Organizations
- Finnish Cultural Foundation
- Northern Savo Cancer Foundation
- K. Albin Johanssons Stiftelse Foundation
- Finnish Glycoscience Graduate School
- Matti ja Vappu Maukosen Foundation
- Kuopio University Foundation
- GGS graduate school
- DPMM
- Paavo Koistisen
- Club Foundation
- Academy of Finland (AKA) [275147, 275147] Funding Source: Academy of Finland (AKA)
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Electrophilic nitrated-fatty acids (NO2-FA, nitroalkenes) are formed during reactions of NO-derived oxidized species (center dot NO, center dot NO2) with either free or esterified polyunsaturated fatty acids. Due to their electrophilic character, they react with nucleophiles such as cysteine thiols in signaling proteins, thereby triggering downstream signaling cascades. Herein, we review two stress-signaling pathways activated by nitroalkenes, the KEAP1-NRF2 signaling pathway and the heat shock response (HSR) pathway. In addition, their biological and pharmacological relevance are discussed. Given that perturbations in both proteostasis and redox balance are common in many disease processes, dual activation of both pathways by nitroalkenes is a promising pharmacological approach for their treatment.
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