Tungstic acid-functionalized MCM-41 as a novel mesoporous solid acid catalyst for the one-pot synthesis of new pyrrolo[2,1-a]isoquinolines

Tungstic acid-functionalized MCM-41 (MCM-41-HWO4) was prepared, characterized and applied as a reusable mesoporous catalyst for the one-pot synthesis of new pyrrolo[2,1-alisoquinoline derivatives. The characterization was performed using FT-IR, X-ray diffraction patterns (XRD), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Pyrrolo[2,1-alisoquinolines were prepared in the presence of this novel MCM-41 based nanocatalyst via the four-component reaction of arylaldehydes, Meldrum's acid, isoquinoline and alkyl isocyanides. MCM-41-HWO4 is a Low-cost and nontoxic heterogeneous catalyst which provides green reaction conditions. Additionally, it can be reused many times without a significant Loss of activity.