Journal
INTERNATIONAL JOURNAL OF ORAL SCIENCE
Volume 5, Issue 2, Pages 66-70Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ijos.2013.36
Keywords
dental lamina; growth factor signalling; mammal; epithelial stem cells diphyodonty; polyphyodonty; reptile; successional lamina; tooth replacement; Zahnreihen; zone of inhibition
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Funding
- Open Fund of State Key Laboratory of Oral Diseases, Sichuan University
- NSERC
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Tooth replacement is a common trait to most vertebrates, including mammals. Mammals, however, have lost the capacity for continuous tooth renewal seen in most other vertebrates, and typically have only 1-2 generations of teeth. Here, we review the mechanisms of tooth replacement in reptiles and mammals, and discuss in detail the current and historical theories on control of timing and pattern of tooth replacement and development.
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