Journal
NEW JOURNAL OF CHEMISTRY
Volume 42, Issue 13, Pages 11147-11152Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj01709c
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Funding
- Natural Science Foundation of China [21377046]
- Natural Science Foundation of Shandong Province [ZR201702070162]
- Special Project of Independent Innovation and Achievements Transformation of Shandong Province [2014ZZCX05101]
- Science and Technology Development Plan Project of Shandong Province [2014GGH217006]
- UJN [ts20130937]
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Herein, a facile and effective turn-on fluorescent sensor for Hg2+ detection was proposed, which is based on graphene oxide (GO) and DNA aptamers. In this assay, GO played a role as a nanoquencher to quench the fluorescence of acridine orange (AO). DNA aptamers (P2 and H-G4) acted as the molecular recognition probes, which could react with Hg2+ specifically and result in the formation of thymine-Hg2+-thymine (T-Hg2+-T) structures and a G-quadruplex. The G-quadruplex could absorb AO from the GO surface, leading to the fluorescence recovery of AO. Based on this recovery of the fluorescence signal, the target Hg2+ (0.5-50 nM) could be detected quantitatively, and the limit of detection (LOD) is 0.17 nM. This novel strategy will have great potential to monitor Hg2+ in the environment.
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