Journal
NEW JOURNAL OF CHEMISTRY
Volume 42, Issue 13, Pages 10704-10711Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj01562g
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Funding
- DST, India [EMR/2016/007022]
- Institute for Basic Science [IBS-R019-D1]
- BK21 Plus Program - Ministry of Education
- National Research Foundation of Korea
- King Fahd University of Petroleum and Minerals [IN171005]
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To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C boolean AND N)(C)Cl][PF6] (2) and [Au(C boolean AND N)(C)Cl][PF6](2) (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(III)-NHC complex is more potent than its Pt analogue.
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