Journal
NEW JOURNAL OF CHEMISTRY
Volume 42, Issue 3, Pages 1600-1603Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nj03829a
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Funding
- DAIP project [859/2016]
- CONACYT project [CB-2016-285622]
- CONACYT [425598/265314, 554166/290817]
- PRODEP [12413143]
- Laboratorio Nacional de Caracterizacion de Propiedades Fisicoquimicas y Estructura Molecular (CONACYT-Mexico) [123732]
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Six novel tris-heterocycles 1'-tetrazolylmethyl-spiro[pyrrolidine-3,3'-oxindoles] were synthesized in 39-82% yields in two experimental steps: (i) a one-pot Ugi-azide/Pictet-Spengler process coupled to (ii) a one-pot oxidative spiro-rearrangement. The synthesized polyheterocycles could be used for further in vitro studies because they contain moieties present in various anticancer bioactive molecules and drugs.
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