Journal
NEUROTOXICOLOGY
Volume 68, Issue -, Pages 88-90Publisher
ELSEVIER
DOI: 10.1016/j.neuro.2018.07.005
Keywords
C. elegans; Glucose; Advanced glycation end products; Neurodegeneration
Categories
Funding
- NIEHS [R01 ES07331, R01 ES10563, R01 ES020852]
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Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.
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