Journal
NEUROSCIENCE RESEARCH
Volume 131, Issue -, Pages 1-9Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2017.09.005
Keywords
Sirt7; EAE; Epigenetic; Multiple sclerosis; Neuroinflammation; Adult neurogenesis
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Funding
- German Research Foundation (DFG) [CRC-TR-128]
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Epigenetic regulators are increasingly recognized as relevant modulators in the immune and nervous system. The class of sirtuins consists of NAD(+)-dependent histone deacetylases that regulate transcription. Sirtuin family member Sirt1 has already been shown to influence the disease course in an animal model of autoimmune neuroinflammation (experimental autoimmune encephalomyelitis (EAE). A role of Sirt7, a related epigenetic regulator, on immune system regulation has been proposed before, as these mice are more susceptible to develop inflammatory cardiomyopathy. Sirt7(-/-) animals showed no differences in clinical score compared to wild-type littermates after EAE induction with myelin oligodendrocyte glycoprotein (MOG) peptide(35-55), although we found subtle immune alterations at different phases of EAE and decreased survival of newly generated neurons in the hippocampus. Our data indicate that Sirt7 has a slight protective impact on both the adaptive immune system and neurogenesis. However, overall this epigenetic factor is not capable of impacting the acute or chronic phase of neuroinflammation. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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