Journal
NEUROSCIENCE LETTERS
Volume 689, Issue -, Pages 45-55Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2018.07.021
Keywords
Astrocytes; Reactive gliosis; Intermediate filaments (Nanofilaments); GFAP; Vimentin; Nestin; Stroke; Brain ischemia; Perinatal asphyxia; The complement system; C3; C3a; Neural plasticity; Brain repair
Categories
Funding
- Swedish Medical Research Council [2017-02255, 2017-00991]
- ALF Gothenburg [146051, 716591]
- AFA Research Foundation
- Soderbergs Foundations
- Sten A. Olsson Foundation for Research and Culture
- Hjarnfonden
- Hagstromer's Foundation Millennium
- Amlov's Foundation
- E. Jacobson's Donation Fund
- VINNOVA
- Swedish Stroke Foundation
- NanoNet COST Action [BM1002]
- EU FP 7 Program TargetBraIn [279017]
- Swedish Research Council [2017-02255, 2017-00991] Funding Source: Swedish Research Council
- Vinnova [2017-02255, 2017-00991] Funding Source: Vinnova
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Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.
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