Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 84, Issue -, Pages 116-133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2017.11.011
Keywords
Cognition; Post-operative cognitive dysfunction; Biomarkers; Neuroinflammation; Oxidative stress
Categories
Funding
- Sydney Parker Smith bequest
- Centre for Research Cooperation in Mental Health scholarships
- NHMRC [1059660]
- Brain and Behavior Foundation
- Marion and EH Flack Trust
- Simons Autism Foundation
- Australian Rotary Health
- Stanley Medical Research Institute
- Deakin University
- Brazilian Society Mobility Program
- Lilly
- NHMRC
- Australasian Society for Bipolar and Depressive Disorders
- Servier
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Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.
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