Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 88, Issue -, Pages 63-72Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.03.014
Keywords
BDNF; p11; Homerla; AMPA receptors; Antidepressant therapy
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Funding
- German Research Council (DFG) [CA 115/5-4, BI 668/2-2, BI 668/5-1, SE 2666/2-1]
- European Union
- German Ministry for Research and Education (BMBF) [B: 031 6174A]
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There is an urgent, unmet clinical need for faster and more efficient antidepressant drugs with higher response rates. In animal models of depression it was shown in the last few years that inhibition of three signaling molecules (BDNF, p11 and Homerla) prevents efficacy of antidepressant therapy. These data not only show the crucial role of these factors for the treatment of depression, but may also point towards a better understanding of the molecular changes responsible for successful antidepressant therapy. Reviewing the literature concerning BNDF, p11 and Homerla we here describe a molecular network in which these molecules interact with each other finally leading to facilitation of AMPA receptor signaling and plasticity, corroborating the current idea of AMPA receptors being a promising drug target in depression.
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