Journal
NEUROPHARMACOLOGY
Volume 137, Issue -, Pages 297-308Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2018.05.015
Keywords
Adrenergic receptors; Anticonvulsant; Mechanism of action; Norepinephrine; Proconvulsant
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Norepinephrine (NE) has been shown to exert a potent suppressant effect on seizure development. On the other hand, several lines of evidence have shown that increased NE level is proconvulsant under certain conditions. These data suggest that variations in NE levels could affect modulatory action of noradrenergic system on seizures. Less, however, is known about the mechanisms by which adrenergic pathways protect against seizures or promote seizures. Knowing the mechanisms involved in anti- or proconvulsive effects of NE may help to the development of new therapeutic candidates for patients with refractory epilepsy. Here, we present some possible mechanisms involved in actions of NE on seizures. (C) 2018 Elsevier Ltd. All rights reserved.
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