Journal
NEUROPATHOLOGY
Volume 38, Issue 4, Pages 422-427Publisher
WILEY
DOI: 10.1111/neup.12471
Keywords
BRAF V600E; diffuse intrinsic pontine glioma; H3F3A; IDH; K27M
Categories
Funding
- Japanese Society for the Promotion of Science (KAKENHI) [16 K10779, 16 K20015, 17 K16652, 17 K10868]
- Grants-in-Aid for Scientific Research [16K10779] Funding Source: KAKEN
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The 2016 edition of the World Health Organization Classification of Tumors of the Central Nervous System introduced diffuse midline glioma H3 K27M mutant as a new diagnostic entity. These tumors predominately affect pediatric patients and arise from midline structures such as the brainstem, thalamus and spinal cord. Here, we report a rare patient with spinal ganglioglioma carrying an H3 K27M mutation. A 10-year-old boy presented with an intramedullary tumor in the cervical spinal cord. The lesion was partially removed and histologically diagnosed as ganglioglioma. After the remnant tumor grew within 3months after surgery, the patient underwent radiotherapy. Genetic analyses revealed an H3F3A K27M mutation but no other genetic alterations such as IDH and BRAF mutations. This case may point to pathological heterogeneity in gliomas with H3 K27M mutations.
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