Journal
NEURON
Volume 98, Issue 2, Pages 297-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2018.03.015
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Funding
- NIH [F30MH106253, NS080675, R01NS084028, R01NS085419, R01NS094692, F31NS089135, MH102471, R01 NS099429, R01 NS078223]
- McDonnell Center for Systems Neuroscience
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Systems-level organization in spontaneous infra-slow (<0.1Hz) brain activity, measured using blood oxygen signals in fMRI and optical imaging, has become a major theme in the study of neural function in both humans and animal models. Yet the neurophysiological basis of infra-slow activity (ISA) remains unresolved. In particular, is ISA a distinct physiological process, or is it a low-frequency analog of faster neural activity? Here, using whole-cortex calcium/hemoglobin imaging in mice, we show that ISA in each of these modalities travels through the cortex along stereotypical spatiotemporal trajectories that are state dependent (wake versus anesthesia) and distinct from trajectories in delta (1-4 Hz) activity. Moreover, mouse laminar electrophysiology reveals that ISA travels through specific cortical layers and is organized into unique cross-laminar temporal dynamics that are different from higher frequency local field potential activity. These findings suggest that ISA is a distinct neuro-physiological process that is reflected in fMRI blood oxygen signals.
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